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ea0026p134 | Growth factors | ECE2011

Circulating insulin-like growth factor 1 (IGF1) and mortality: meta-analysis and dose-response meta-regression

Burgers A M G , Biermasz N R , Schoones J W , Pereira A M , Renehan A G , Zwahlen M , Egger M , Dekkers O M

Background: Insulin-like growth factor 1 (IGF1) plays a central role in metabolism and growth regulation. High IGF1 levels are associated with an increased risk of cancer, low IGF1 levels with increased risk for cardiovascular disease. We hypothesized that the relationship between circulating total IGF1 levels and mortality is U-shaped.Methods: We performed a systematic review searching PubMed, EMBASE, Web of Science, Cochrane Library (1985 to September ...

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ea0026p256 | Pituitary | ECE2011

Low incidence of adrenal insufficiency after transsphenoidal surgery in patients with acromegaly: a long-term follow-up study

Burgers A M G , Kokshoorn N E , Pereira A M , Roelfsema F , Smit J W A , Biermasz N R , Romijn J A

Background: The long-term prevalence of adrenal insufficiency after transsphenoidal surgery for GH secreting pituitary adenomas was unknown. However, recently a single study reported a high prevalence of adrenal insufficiency after surgical and/or medical treatment without postoperative radiotherapy in acromegalic patients.Aim: To assess the prevalence and incidence rate of adrenal insufficiency in consecutive patients during long-term follow-up after su...

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Endocrine Abstracts

Circulating insulin-like growth factor 1 (IGF1) and mortality: meta-analysis and dose-response meta-regression

Low incidence of adrenal insufficiency after transsphenoidal surgery in patients with acromegaly: a long-term follow-up study

BiosciAbstracts